A brominated uridine analog; can be incorporated into RNA and subsequently detected by antibodies against bromodeoxyuridine; decreases the viability of HL-60 and MOLT-4 cells (LC50s = 10 and 20 μM

5-Bromouridine – 1 g

Brand:
Cayman
CAS:
957-75-5
Storage:
-20
UN-No:
Non-Hazardous - /

5-Bromouridine is a brominated analog of the nucleoside uridine (Item No. 20300).{46879} It can be incorporated into RNA and subsequently detected by antibodies against bromodeoxyuridine (Item No. 15580).{46880} 5-Bromouridine decreases the viability of HL-60 and MOLT-4 cells (LC50s = 10 and 20 μM, respectively). It induces apoptosis and halts the cell cycle at the S phase in HL-60 cells. It is photoreactive, and UV irradiation has been used to cross-link RNA containing 5-bromouridine to proteins in the study of of RNA-protein interactions.{46879,46881} 5-Bromouridine can also be incorporated into RNA using 5-bromouridine 5’-triphosphate (Item No. 18140).  

 

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SKU: 30457 - 1 g Category:

Description

A brominated uridine analog; can be incorporated into RNA and subsequently detected by antibodies against bromodeoxyuridine; decreases the viability of HL-60 and MOLT-4 cells (LC50s = 10 and 20 μM, respectively); induces apoptosis and halts the cell cycle at the S phase in HL-60 cells; photoreactive; UV irradiation has been used to cross-link RNA containing 5-bromouridine to proteins in the study of RNA-protein interactions; can be incorporated into RNA using 5-bromouridine 5’-triphosphate

Formal name: 5-bromo-uridine

Synonyms:  (–)-5-Bromouridine|BrU|BrUrd|NSC 38296

Molecular weight: 323.1

CAS: 957-75-5

Purity: ≥98%

Formulation: A solid

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