An SPHK2 inhibitor (Ki = 0.4 μM for the recombinant mouse enzyme); selective for SPHK2 over SPHK1 (Kis = >20 μM); decreases S1P and increases sphingosine levels in U937 monocytic leukemia cells in a concentration-dependent manner; reduces blood S1P levels in Sphk1-/-

SLM6031434 (hydrochloride) – 10 mg

Brand:
Cayman
CAS:
1897379-34-8
Storage:
-20
UN-No:
Non-Hazardous - /

SLM6031434 is an inhibitor of sphingosine kinase 2 (SPHK2) (Ki = 0.4 μM for the recombinant mouse enzyme).{38413} It is selective for SPHK2 over SPHK1 (Kis = >20 μM). It decreases sphingosine-1-phosphate (S1P; Item No. 62570) and increases sphingosine levels in U937 monocytic leukemia cells in a concentration-dependent manner. SLM6031434 (5 mg/kg) reduces blood S1P levels in Sphk1-/-, but not Sphk2-/-, mice. SLM6031434 also increases blood S1P levels in wild-type mice and rats.  

 

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Description

An SPHK2 inhibitor (Ki = 0.4 μM for the recombinant mouse enzyme); selective for SPHK2 over SPHK1 (Kis = >20 μM); decreases S1P and increases sphingosine levels in U937 monocytic leukemia cells in a concentration-dependent manner; reduces blood S1P levels in Sphk1-/-, but not Sphk2-/-, mice at 5 mg/kg; increases blood S1P levels in wild-type mice and rats

Formal name: (2S)-2-[3-[4-(octyloxy)-3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-pyrrolidinecarboximidamide, monohydrochloride

Synonyms: 

Molecular weight: 490

CAS: 1897379-34-8

Purity: ≥98%

Formulation: A crystalline solid

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