Description
A potent, selective, and orally bioavailable PDE4 inhibitor (IC50s = 2.51, 1.58, and 2 nM for PDE4A, PDE4B, and PDE4D, respectively); >100-fold selective for PDE4 over other members of the PDE family, as well as over a panel of 154 diverse receptors, ion channels and enzymes; inhibits LPS-induced release of TNF-α in human whole blood (IC50 = 23.1 nM); reduces LPS-induced neutrophilia in rats (ED50 = 0.09 mg/kg); induces anxiolytic behavior in marmosets at 0.01-1 mg/kg; improves performance of non-human primates in an object retrieval test at 1 mg/kg
Formal name: 5-[5-[(2,4-dimethyl-5-thiazolyl)methyl]-1,3,4-oxadiazol-2-yl]-1-ethyl-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine
Synonyms:
Molecular weight: 439.5
CAS: 720704-34-7
Purity: ≥98%
Formulation: A crystalline solid
