Description
A potent and selective PDE9A inhibitor (IC50s = 65 and 168 nM for the human and rat enzymes, respectively); selective for PDE9A over PDE2A, -3A, -4B, -5A, -6AB, -7A and -10A and 95 non-PDE targets at 10 µM but inhibits human PDE1A and PDE1C (IC50s = 1.45 and 1.17 µM, respectively); increases mouse striatal cGMP levels at 0.5 mg/kg in combination with MK-801; enhances LTP in hippocampal slices and reverses MK-801-induced working memory deficits in mice at 0.007-2.5 mg/kg
Formal name: 1,5-dihydro-6-(2-pyridinylmethyl)-1-(tetrahydro-2H-pyran-4-yl)-4H-pyrazolo[3,4-d]pyrimidin-4-one
Synonyms:
Molecular weight: 311.3
CAS: 1189767-28-9
Purity: ≥98%
Formulation: A crystalline solid
