A PDE5 inhibitor; increases lung cGMP levels

Udenafil – 10 mg

Brand:
Cayman
CAS:
268203-93-6
Storage:
-20
UN-No:
Non-Hazardous - /

Udenafil is an inhibitor of phosphodiesterase 5 (PDE5).{56058,56059,56060} In vivo, udenafil (1 and 5 mg/kg) increases lung cGMP levels, attenuates the development of compensatory right ventricular hypertrophy, and reduces pulmonary arterial wall thickening in a rat model of monocrotaline-induced pulmonary hypertension.{56058} It increases creatine clearance and decreases blood urea nitrogen (BUN) and serum malondialdehyde (MDA) levels in a rat model of renal ischemia-reperfusion injury.{56059} Udenafil (0.3 and 10 mg/kg) induces penile erections in conscious rabbits and in rabbits with acute spinal cord injury.{56060}  

 

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SKU: 30373 - 10 mg Category:

Description

A PDE5 inhibitor; increases lung cGMP levels, attenuates the development of compensatory right ventricular hypertrophy, and reduces pulmonary arterial wall thickening in a rat model of monocrotaline-induced pulmonary hypertension at 1 and 5 mg/kg; increases creatine clearance and decreases BUN and serum MDA levels in a rat model of renal ischemia-reperfusion injury; induces penile erections in conscious rabbits and in rabbits with acute spinal cord injury at 0.3 and 10 mg/kg

Formal name: 3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-N-[2-(1-methyl-2-pyrrolidinyl)ethyl]-4-propoxy-benzenesulfonamide

Synonyms:  DA-8159

Molecular weight: 516.7

CAS: 268203-93-6

Purity: ≥95%

Formulation: A crystalline solid

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