A sesquiterpene with diverse biological activities; reduces the cytopathic effect of influenza A in MDCK cells (IC50 = 28.32 μM); inhibits thrombin-induced aggregation

Curdione – 1 mg

Brand:
Cayman
CAS:
13657-68-6
Storage:
-20
UN-No:
Non-Hazardous - /

Curdione is a sesquiterpene that has been found in C. wenyujin and has diverse biological activities. It reduces the cytopathic effect of influenza A in MDCK cells (IC50 = 28.32 μM).{52521} Curdione (100 μM) inhibits thrombin-induced aggregation, AMP-activated protein kinase (AMPK) and integrin αIIbβ3 phosphorylation, and increases in talin and vinculin levels in washed platelets.{52522} It inhibits prostaglandin E2 (PGE2; Item No. 14010) production in LPS-stimulated RAW 264.7 macrophages (IC50 = 1.12 μM).{52523}  

 

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Description

A sesquiterpene with diverse biological activities; reduces the cytopathic effect of influenza A in MDCK cells (IC50 = 28.32 μM); inhibits thrombin-induced aggregation, AMPK and integrin αIIbβ3 phosphorylation, and increases in talin and vinculin levels in washed platelets at 100 μM; inhibits PGE2 production in LPS-stimulated RAW 264.7 macrophages (IC50 = 1.12 μM)

Formal name: (3S,6E,10S)-6,10-dimethyl-3-(1-methylethyl)-6-cyclodecene-1,4-dione

Synonyms:  (+)-Curdione

Molecular weight: 236.3

CAS: 13657-68-6

Purity: ≥98%

Formulation: A crystalline solid

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