An antiallergic agent; inhibits IL-4 and IL-5 production in conalbumin-stimulated D10.G4.1 murine Th2 cells in a concentration-dependent manner; inhibits ovalbumin-induced increases in eosinophil and total cell numbers

Suplatast (tosylate) – 1 g

Brand:
Cayman
CAS:
94055-76-2
Storage:
-20
UN-No:
Non-Hazardous - /

Suplatast is an antiallergic agent.{53624,53625} It inhibits IL-4 and IL-5 production in conalbumin-stimulated D10.G4.1 murine T helper 2 (Th2) cells in a concentration-dependent manner.{53624} Suplatast (100 mg/kg) inhibits ovalbumin-induced increases in eosinophil and total cell numbers, as well as IL-4, IL-5, and IL-13, but not IFN-γ, levels in bronchoalveolar lavage fluid (BALF) in an ovalbumin-sensitized mouse model of asthma.{53625} It also inhibits ovalbumin-induced increases in ovalbumin-specific IgE in serum and bronchial hyperresponsiveness to methacholine in the ovalbumin-sensitized mouse model of asthma.  

 

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SKU: 30316 - 1 g Category:

Description

An antiallergic agent; inhibits IL-4 and IL-5 production in conalbumin-stimulated D10.G4.1 murine Th2 cells in a concentration-dependent manner; inhibits ovalbumin-induced increases in eosinophil and total cell numbers, as well as IL-4, IL-5, and IL-13, but not IFN-γ, levels in BALF in an ovalbumin-sensitized mouse model of asthma at 100 mg/kg; inhibits ovalbumin-induced increases in ovalbumin-specific IgE in serum and bronchial hyperresponsiveness to methacholine in the ovalbumin-sensitized mouse model of asthma

Formal name: [3-[[4-(3-ethoxy-2-hydroxypropoxy)phenyl]amino]-3-oxopropyl]dimethyl-sulfonium, 4-methylbenzenesulfonate

Synonyms: 

Molecular weight: 499.6

CAS: 94055-76-2

Purity: ≥98%

Formulation: A crystalline solid

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