Description
A phthalide with diverse biological activities; inhibits ADP-, thrombin-, and arachidonic acid-induced aggregation of isolated washed human platelets at 30, 100, and 300 µM, respectively; inhibits ADP-induced phosphorylation of cPLA2 and thrombin- or collagen-induced TXA2 production isolated washed human platelets at 30-300 µM; inhibits caspase-3 activation, decreases ROS production and JNK phosphorylation, and prevents serum deprivation-induced cell death in primary mouse cortical neurons at 10 µM; reduces infarct volume, as well as caspase-3 activation and JNK phosphorylation in the peri-infarct region, in a mouse model of MCAO with bilateral common carotid artery ligation at 100 mg/kg administered one following occlusion
Formal name: 3-butyl-1(3H)-isobenzofuranone
Synonyms: (±)-3-Butylphthalide|(±)-NBP|dl-3-n-Butylphthalide
Molecular weight: 190.2
CAS: 6066-49-5
Purity: ≥98%
Formulation: A neat oil
