An α-keto acid; a key component of cellular metabolism in its conjugate base form

Oxaloacetic Acid – 5 g

Brand:
Cayman
CAS:
328-42-7
Storage:
-20
UN-No:
Non-Hazardous - /

Oxaloacetic acid is an α-keto acid and a key component of cellular metabolism in its conjugate base form, oxaloacetate.{57040,57041,57042} Oxaloacetate reacts with acetyl-coenzyme A (acetyl-CoA; Item No. 16160) and water to form citrate in the first step of the citric acid cycle and is regenerated by oxidation of L-malate in the final step.{57041} It is an intermediate in gluconeogenesis that is formed in mitochondria via carboxylation of pyruvate and subsequently decarboxylated and phosphorylated to form phosphoenolpyruvate.{57042} It can be converted to aspartate via addition of an amino group from glutamate.{57040} Oxaloacetate (30 μmol/min per 100 g for 30 minutes, i.v.) reduces blood glutamate levels, severity of neurological dysfunction, and brain edema in a rat model of closed head injury.{57043}  

 

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Description

An α-keto acid; a key component of cellular metabolism in its conjugate base form, oxaloacetate; reacts with acetyl-CoA and water as oxaloacetate to form citrate in the first step of the citric acid cycle and is regenerated in the final step; an intermediate in gluconeogenesis as oxaloacetate; reduces blood glutamate levels, severity of neurological dysfunction, and brain edema in a rat model of closed head injury at 30 μmol/min per 100 g for 30 minutes, i.v. administered as the oxaloacetate form

Formal name: 2-oxo-butanedioic acid

Synonyms:  NSC 284205|NSC 77688|OAA|Oxalacetic Acid

Molecular weight: 132.1

CAS: 328-42-7

Purity: ≥95%

Formulation: A solid

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