Description
A modulator of CFTR; inhibits CFTR in T84 human colon cells (IC50 = 8.51 µM); has rapid inhibitory and slow potentiating effects on human CFTR with apparent Kd values of 6.1 and 0.64 nM, respectively; potentiates currents through ΔF508-CFTR expressed in X. laevis oocytes at 20 nM; inhibits mouse CFTR with an apparent Kd value of 42.9 µM
Formal name: 3-(3,5-dibromo-4-hydroxyphenyl)-N-[(4-phenoxyphenyl)methyl]-1,2,4-oxadiazole-5-carboxamide
Synonyms:
Molecular weight: 545.2
CAS: 1191252-49-9
Purity: ≥98%
Formulation: A crystalline solid
