A hepatoprotective agent; inhibits A23187-induced metabolism of arachidonic acid to the 5-LO metabolites LTB4 and 5-HETE in macrophages isolated from the ascitic fluid of patients with alcoholic liver cirrhosis; prevents increases in plasma GPT and GOT activities in a rat model of carbon tetrachloride-induced liver injury at 50 mg/kg; reduces hepatic deposition of type III procollagen

Malotilate – 5 g

Brand:
Cayman
CAS:
59937-28-9
Storage:
-20
UN-No:
Non-Hazardous - /

Malotilate is a hepatoprotective agent.{46922} It inhibits A23187-induced metabolism of arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) to the 5-lipoxygenase (5-LO) metabolites leukotriene B4 (LTB4; Item No. 20110) and 5-HETE in macrophages isolated from the ascitic fluid of patients with alcoholic liver cirrhosis. Malotilate (50 mg/kg) prevents increases in plasma glutamic-pyruvic transaminase (GPT) and glutamic-oxaloacetic transaminase (GOT) activities in a rat model of carbon tetrachloride-induced liver injury.{46923} It reduces hepatic deposition of type III procollagen, type IV collagen, laminin, and fibronectin in a rat model of dimethylnitrosamine-induced hepatic fibrosis when administered at a dose of 100 mg/kg.{46924}  

 

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SKU: 30266 - 5 g Category:

Description

A hepatoprotective agent; inhibits A23187-induced metabolism of arachidonic acid to the 5-LO metabolites LTB4 and 5-HETE in macrophages isolated from the ascitic fluid of patients with alcoholic liver cirrhosis; prevents increases in plasma GPT and GOT activities in a rat model of carbon tetrachloride-induced liver injury at 50 mg/kg; reduces hepatic deposition of type III procollagen, type IV collagen, laminin, and fibronectin in a rat model of dimethylnitrosamine-induced hepatic fibrosis at 100 mg/kg

Formal name: 2-(1,3-dithiol-2-ylidene)-propanedioic acid, 1,3-bis(1-methylethyl) ester

Synonyms:  NKK-105

Molecular weight: 288.4

CAS: 59937-28-9

Purity: ≥98%

Formulation: A solid

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