A gastroprotective agent; increases transfer of Lucifer yellow CH between isolated rabbit gastric epithelial cells

Irsogladine (maleate) – 500 mg

Brand:
Cayman
CAS:
84504-69-8
Storage:
-20
UN-No:
Non-Hazardous - /

Irsogladine is a gastroprotective agent.{55063,55064,55065} It increases transfer of Lucifer yellow CH (Item No. 25573) between isolated rabbit gastric epithelial cells, indicating enhanced gap junction intercellular communication (GJIC).{55064} Irsogladine (3 mg/kg) inhibits gastric mucosal lesion formation and decreases in gastric mucosal blood flow induced by monochloramine in rats, effects that can be prevented by the nitric oxide synthase inhibitor L-NAME (Item No. 80210).{55063} It also inhibits superoxide anion production induced by fMLP (Item No. 21495) and increases cAMP levels in isolated human neutrophils in a concentration-dependent manner, similar to the phosphodiesterase 4 (PDE4) inhibitor rolipram (Item No. 10011132).{55065}  

 

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SKU: 30223 - 500 mg Category:

Description

A gastroprotective agent; increases transfer of Lucifer yellow CH between isolated rabbit gastric epithelial cells, indicating enhanced GJIC; inhibits gastric mucosal lesion formation and decreases in gastric mucosal blood flow induced by monochloramine in rats at 3 mg/kg, effects that can be prevented by L-NAME; inhibits fMLP-induced superoxide anion production and increases cAMP levels in isolated human neutrophils in a concentration-dependent manner, similar to rolipram

Formal name: 6-(2,5-dichlorophenyl)-1,3,5-triazine-2,4-diamine, 2Z-butenedioate

Synonyms: 

Molecular weight: 372.2

CAS: 84504-69-8

Purity: ≥98%

Formulation: A crystalline solid

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