An anti-inflammatory agent; inhibits rat seminal vesicle PGH2 synthase (IC50 = 120 µM)

SKF 86002 – 5 mg

Brand:
Cayman
CAS:
72873-74-6
Storage:
-20
UN-No:
Non-Hazardous - /

SKF 86002 is an anti-inflammatory agent.{53596,16230,53597,53598} It inhibits rat seminal vesicle prostaglandin H2 (PGH2) synthase (IC50 = 120 µM), as well as prostanoid production by rat basophilic leukemia (RBL-1) cells and human monocytes (IC50s = 70 and 1 µM, respectively).{53596} SKF 86002 inhibits leukotriene B4 (LTB4) and LTC4 production induced by A23187 (Item No. 11016) in human neutrophils and monocytes, respectively (IC50 = 20 µM for both). It also inhibits LPS-induced IL-1 production in human monocytes (IC50 = 1.3 µM).{16230} SKF 86002 (10, 30, and 90 mg/kg) reduces hindleg volume in rat models of adjuvant- or collagen-induced arthritis.{53597} It also decreases serum levels of TNF-α and increases survival in a mouse model of LPS and galactosamine-induced endotoxic shock when administered at a dose of 100 mg/kg.{53598}  

 

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SKU: 30202 - 5 mg Category:

Description

An anti-inflammatory agent; inhibits rat seminal vesicle PGH2 synthase (IC50 = 120 µM), as well as prostanoid production by RBL-1 cells and human monocytes (IC50s = 70 and 1 µM, respectively); inhibits A23187-induced LTB4 and LTC4 production in human neutrophils and monocytes, respectively (IC50 = 20 µM for both); inhibits LPS-induced IL-1 production in human monocytes (IC50 = 1.3 µM); reduces hindleg volume in rat models of adjuvant- or collagen-induced arthritis at 10, 30, and 90 mg/kg; decreases serum levels of TNF-α and increases survival in a mouse model of LPS- and galactosamine-induced endotoxic shock at 100 mg/kg

Formal name: 6-(4-fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)-imidazo[2,1-b]thiazole

Synonyms: 

Molecular weight: 297.4

CAS: 72873-74-6

Purity: ≥98%

Formulation: A crystalline solid

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