Description
An anti-inflammatory agent; inhibits rat seminal vesicle PGH2 synthase (IC50 = 120 µM), as well as prostanoid production by RBL-1 cells and human monocytes (IC50s = 70 and 1 µM, respectively); inhibits A23187-induced LTB4 and LTC4 production in human neutrophils and monocytes, respectively (IC50 = 20 µM for both); inhibits LPS-induced IL-1 production in human monocytes (IC50 = 1.3 µM); reduces hindleg volume in rat models of adjuvant- or collagen-induced arthritis at 10, 30, and 90 mg/kg; decreases serum levels of TNF-α and increases survival in a mouse model of LPS- and galactosamine-induced endotoxic shock at 100 mg/kg
Formal name: 6-(4-fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)-imidazo[2,1-b]thiazole
Synonyms:
Molecular weight: 297.4
CAS: 72873-74-6
Purity: ≥98%
Formulation: A crystalline solid
