Description
A STING agonist; induces expression of an ISG54 luciferase reporter in HepAD38 cells that constitutively express human cGAS and STING; increases IFNB1, TNFA, and IL29 expression in HepG2 cells expressing wild-type human, but not C-terminal truncated human or mouse, STING, as well as in isolated human PBMCs at 50 µM; inhibits yellow fever, dengue, and Zika virus replication in THF fibroblasts at 50 µM
Formal name: (5′aS,10′aS)-1′,5′a,6′,10′a-tetrahydro-dispiro[2H-indene-2,3′-[3H,5H,8H,10H]bisthiazolo[3,4-a:3′,4′-d]pyrazine-8′,2″-[2H]indene]-1,1″,3,3″,5′,10′-hexone
Synonyms: ZINC03129319
Molecular weight: 490.5
CAS: 1777807-64-3
Purity: ≥98%
Formulation: A solid
