A phenylethanoid glycoside; active against E. coli

Forsythoside A – 10 mg

Brand:
Cayman
CAS:
79916-77-1
Storage:
-20
UN-No:
Non-Hazardous - /

Forsythoside A is a phenylethanoid glycoside that has been found in F. suspensa and has diverse biological activities.{52386,52387,52388,52389} It is active against E. coli, P. aeruginosa, and S. aureus (MICs = 38.33, 38.33, and 76.67 µg/ml, respectively).{52386} Forsythoside A scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals with an EC50 value of 6.3 µg/ml. It reduces apoptosis induced by amyloid-β (25-35) (Aβ (25-35)) in PC12 cells when used at concentrations of 10 and 25 µM.{52388} Forsythoside A (15, 30, and 60 mg/kg per day) reduces increases in bronchoalveolar lavage fluid (BALF) levels of TNF-α, IL-6, and IL-1β and neutrophil and macrophage infiltration induced by cigarette smoke in a mouse model of chronic obstructive pulmonary disease (COPD).{52387} It decreases the latency mice take to find the platform in the Morris water maze in the SAMP8 model of rapid aging and dementia when administered at doses of 120 and 240 mg/kg per day.{52389}  

 

Available on backorder

Add to quotes
SKU: 30110 - 10 mg Category:

Description

A phenylethanoid glycoside; active against E. coli, P. aeruginosa, and S. aureus (MICs = 38.33, 38.33, and 76.67 µg/ml, respectively); scavenges DPPH radicals (EC50 = 6.3 µg/ml); prevents Aβ (25-35)-induced apoptosis in PC12 cells at 10 and 25 µM; reduces cigarette smoke-induced increases in BALF levels of TNF-α, IL-6, and IL-1β and neutrophil and macrophage infiltration in a mouse model of COPD at 15, 30, and 60 mg/kg per day; decreases the latency mice take to find the platform in the Morris water maze in the SAMP8 model of rapid aging and dementia at 120 and 240 mg/kg per day

Formal name: 2-(3,4-dihydroxyphenyl)ethyl 6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-Glucopyranoside, 4-[(2E)-3-(3,4-dihydroxyphenyl)-2-propenoate]

Synonyms:  Forsythiaside

Molecular weight: 624.6

CAS: 79916-77-1

Purity: ≥98%

Formulation: A crystalline solid

Related products

  • A powerful effector in both the TetR and revTetR transcriptional regulator systems

    Anhydrotetracycline (hydrochloride) – 250 mg

    The tetracycline repressor (TetR) is a transcriptional regulator which normally binds tightly to its palindromic tetO operator DNA, blocking gene expression.{17508} Tet causes the repressor to dissociate from the DNA, allowing transcription to occur. A novel reverse TetR (revTetR) requires tetracycline as a co-repressor to bind tetO and block transcription.{17509,17510} Anhydrotetracycline (hydrochloride) is a powerful effector in both the tetracycline repressor (TetR) and reverse TetR (revTetR) systems, binding the Tet repressor 35-fold more strongly than Tet.{17508,17511} Moreover, anhydrotetracycline poorly binds the 30S ribosomal subunit, compared to Tet,{17512} so it does not act as a general inhibitor of translation and is a poor antibiotic. Perhaps related to this, the concentration of anhydrotetracycline that inhibits eukaryotic cell growth is more than a 1,000-fold above the dose that alters transcription through TetR.{17508}  

     

    Brand:
    Cayman
    SKU:10009542 - 250 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • PtdIns-(3

    PtdIns-(3,4,5)-P3-biotin (sodium salt) – 100 µg

    The PtdIn phosphates play an important role in the generation and transduction of intracellular signals.{8344,4096,14518} PtdIns-(3,4,5)-P3-biotin is an affinity probe which allows the PIP3 to be detected through an interaction with the biotin ligand. This design allows PtdIns-(3,4,5)-P3-biotin to serve as a general probe for any protein with a high affinity binding interaction with inositol-(3,4,5)-triphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.  

     

    Brand:
    Cayman
    SKU:10009531 - 100 µg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • A potent inhibitor of Cdk2/cyclin E with an IC50 value of 0.1 µM; also inhibits Cdk7/cyclin H

    (R)-Roscovitine – 1 mg

    Cyclin-dependent kinases (CDKs) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. (R)-Roscovitine is a potent inhibitor of Cdk2/cyclin E with an IC50 value of 0.1 µM.{14988} It also inhibits Cdk7/cyclin H, Cdk5/p35, and cell division cycle (cdc)/cyclin B with IC50 values of 0.49, 0.16, and 0.65 µM, respectively.{14987,14988,14991} (R)-Roscovitine inhibits the growth of rapidly proliferating cells with an average IC50 value of 15.2 µM against a panel of 19 human tumor cell lines.{14988} In murine models of polycystic kidney disease, (R)-roscovitine effectively inhibited disease progression at doses of 50-100 mg/kg.{14564}  

     

    Brand:
    Cayman
    SKU:10009569 - 1 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}

    CAY10512 – 100 mg

    The nuclear factor-κB (NF-κB) regulates the expression of numerous genes involved in immunity and inflammation, cellular stress responses, growth, and apoptosis. Resveratrol, a polyphenolic trans-stilbene, is a known inhibitor of the activation of NF-κB and exhibits activity against a wide variety of cancer cells. CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}  

     

    Brand:
    Cayman
    SKU:10009536 - 100 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page