An imidazole with antimicrobial activity; active against clinical isolates of Candida species with MIC values ranging from 0.12 to 2 μg/ml; active against T. mentagrophytes and T. rubrum at 0.1 µg/ml and the bacteria C. tuberculostearicum

Isoconazole (nitrate) – 1 g

Brand:
Cayman
CAS:
24168-96-5
Storage:
-20
UN-No:
Non-Hazardous - /

Isoconazole is an imidazole with antimicrobial activity.{46541} It is active against clinical isolates of Candida species, including C. albicans, C. parapsilosis, C. tropicalis, C. krusei, and C. guilliermondii with MIC values ranging from 0.12 to 2 μg/ml. It is also active against the fungi T. mentagrophytes and T. rubrum when used at a concentration of 0.1 µg/ml and the bacteria C. tuberculostearicum, methicillin-resistant S. aureus (MRSA), and S. epidermis (MICs = 3.9, 32, and 5.6 mg/L, respectively).{46851,46852} Isoconazole induces the production of reactive oxygen species (ROS) in S. aureus.{46852} It also inhibits heme oxygenase in rat spleen and rat brain microsomes that endogenously express high levels of heme oxygenase-1 (HO-1) and HO-2, respectively (IC50s = 5.6 and 32.6 µM, respectively).{24647}  

 

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SKU: 30100 - 1 g Category:

Description

An imidazole with antimicrobial activity; active against clinical isolates of Candida species with MIC values ranging from 0.12 to 2 μg/ml; active against T. mentagrophytes and T. rubrum at 0.1 µg/ml and the bacteria C. tuberculostearicum, methicillin-resistant S. aureus (MRSA), and S. epidermis (MICs = 3.9, 32, and 5.6 mg/L, respectively); induces ROS production in S. aureus; inhibits HO-1 and HO-2 in rat spleen and rat brain microsomes, respectively (IC50s = 5.6 and 32.6 µM, respectively)

Formal name: 1-[2-(2,4-dichlorophenyl)-2-[(2,6-dichlorophenyl)methoxy]ethyl]-1H-imidazole, mononitrate

Synonyms:  Adestan G 100|R 15454

Molecular weight: 479.1

CAS: 24168-96-5

Purity: ≥98%

Formulation: A solid

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