An anticholinergic agent; induces relaxation of methacholine-precontracted isolated guinea pig trachea strips (EC50 = 0.12 nM); reverses carbachol-induced increases in lung resistance and decreases in dynamic lung compliance in vagotomized cats (ED50s = 17.5 and 19.3 µg/kg

Diphemanil (methyl sulfate) – 250 mg

Brand:
Cayman
CAS:
62-97-5
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Diphemanil is a quaternary ammonium anticholinergic agent.{53536} It induces relaxation of isolated guinea pig trachea strips precontracted with methacholine (EC50 = 0.12 nM). Diphemanil reverses increases in lung resistance and decreases in dynamic lung compliance induced by the non-selective acetylcholine receptor agonist carbachol (carbamoylcholine; Item No. 14486) in vagotomized cats (ED50s = 17.5 and 19.3 µg/kg, respectively). It reduces salivation induced by the muscarinic acetylcholine receptor agonist pilocarpine in mice when administered subcutaneously at doses ranging from 1.25 to 10 mg/kg.{53537}  

 

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SKU: 30090 - 250 mg Category:

Description

An anticholinergic agent; induces relaxation of methacholine-precontracted isolated guinea pig trachea strips (EC50 = 0.12 nM); reverses carbachol-induced increases in lung resistance and decreases in dynamic lung compliance in vagotomized cats (ED50s = 17.5 and 19.3 µg/kg, respectively); reduces pilocarpine-induced salivation in mice from 1.25-10 mg/kg s.c.

Formal name: 4-(diphenylmethylene)-1,1-dimethyl-piperidinium, methyl sulfate

Synonyms:  NSC 41725

Molecular weight: 389.5

CAS: 62-97-5

Purity: ≥98%

Formulation: A liquid

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