A triterpenoid saponin with diverse biological activities; inhibits LPS-induced increases in TNF-α and NO production

Polygalasaponin F – 5 mg

Brand:
Cayman
CAS:
882664-74-6
Storage:
-20
UN-No:
Non-Hazardous - /

Polygalasaponin F is a triterpenoid saponin originally isolated from Polygala japonica and has diverse biological activities.{52413,52414,52415} It inhibits LPS-induced increases in TNF-α and nitric oxide (NO) production, inducible nitric oxide synthase (iNOS) levels, and nuclear translocation of NF-κB p65 in BV-2 microglia when used at concentrations of 0.1, 1, and 10 μM.{52413} Polygalasaponin F (0.1, 1, and 10 μM) inhibits rotenone-induced increases in intracellular reactive oxygen species (ROS) levels, decreases in mitochondrial membrane potential, and induction of apoptosis in PC12 cells.{52414} Intracerebroventricular administration of polygalasaponin F (1 and 10 μM) induces long-term potentiation in the hippocampal dentate gyrus in anesthetized rats, an effect that can be prevented by the NMDA receptor inhibitor MK-801 or the calcium/calmodulin-dependent protein kinase (CaMKII) inhibitor KN-93 (Item Nos. 13319 | 13864 | 21472).{52415}  

 

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SKU: 30064 - 5 mg Category:

Description

A triterpenoid saponin with diverse biological activities; inhibits LPS-induced increases in TNF-α and NO production, iNOS levels, and nuclear translocation of NF-κB p65 in BV-2 microglia at 0.1, 1, and 10 μM; inhibits rotenone-induced increases in intracellular ROS levels, decreases in mitochondrial membrane potential, and induction of apoptosis in PC12 cells at 0.1, 1, and 10 μM; intracerebroventricular administration induces long-term potentiation in the hippocampal dentate gyrus in anesthetized rats at 1 and 10 μM, an effect that can be prevented by MK-801 or KN-93

Formal name: (2β,3β,4α)-3-(β-D-glucopyranosyloxy)-2,23-dihydroxy-olean-12-en-28-oic acid, O-β-D-xylopyranosyl-(1→4)-O-6-deoxy-α-L-mannopyranosyl-(1→2)-β-D-glucopyranosyl ester

Synonyms: 

Molecular weight: 1,091.20

CAS: 882664-74-6

Purity: ≥95%

Formulation: A solid

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