A pyrrolizidine alkaloid; an inhibitor of glucoamylase (IC50 = 5.8 µM); that also inhibits glucosidase I

Australine (hydrochloride) – 1 mg

Brand:
Cayman
CAS:
186766-07-4
Storage:
-20
UN-No:
Non-Hazardous - /

Australine is a pyrrolizidine alkaloid originally isolated from C. australe that has enzyme inhibitory activities.{54015,54016,54017} It is an inhibitor of glucoamylase (IC50 = 5.8 µM) that also inhibits glucosidase I, sucrase, maltase, and A. niger α-glucosidase (IC50s = 20, 28, 35, and 28 µM, respectively).{54016,54017} Australine is selective for these enzymes over glucosidase II, α- and β-mannosidase, and α- and β-galactosidase up to 500 µM, β-glucosidase, with only 5% inhibition at 66 µM, as well as isomaltase and trehalase (IC50 = 97 and 160 µM, respectively). Australine (500 µg/ml) inhibits glycoprotein processing of viral glycoproteins in influenza virus-infected MDCK cells and induces the accumulation of glycoproteins.{54016}  

 

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Description

A pyrrolizidine alkaloid; an inhibitor of glucoamylase (IC50 = 5.8 µM); that also inhibits glucosidase I, sucrase, maltase, and A. niger α-glucosidase (IC50s = 20, 28, 35, and 28 µM, respectively); selective for these enzymes over glucosidase II, α- and β-mannosidase, and α- and β-galactosidase up to 500 µM, β-glucosidase, with only 5% inhibition at 66 µM, as well as isomaltase and trehalase (IC50 = 97 and 160 µM, respectively); inhibits glycoprotein processing of viral glycoproteins in influenza virus-infected MDCK cells and induces the accumulation of glycoproteins at 500 µg/ml

Formal name: (1R,2R,3R,7S,7aR)-hexahydro-3-(hydroxymethyl)-1H-pyrrolizine-1,2,7-triol, monohydrochloride

Synonyms:  (+)-Australine|7a-epi-Alexine

Molecular weight: 225.7

CAS: 186766-07-4

Purity: ≥95%

Formulation: A crystalline solid

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