Description
A 5-HT4 agonist (Ki = 69.9 nM); selective for 5-HT4 over 5-HT1, 5-HT2, dopamine D2, and α1- and α2-adrenergic receptors at 1 mM but also acts as a partial antagonist at 5-HT3 (Ki = 1,189 nM); induces relaxation of precontracted rat esophageal thoracic muscularis mucosa preparations and enhances electrically evoked contractions in isolated guinea pig ileum (EC50s = 208.4 and 73.2 nM, respectively); increases antral and duodenal, but not ileal or colonic, motility in conscious dogs at 0.5 and 1 mg/kg; increases gastric emptying in rats from 0.03-30 mg/kg
Formal name: 4-amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]-2-morpholinyl]methyl]-benzamide, 2-hydroxy-1,2,3-monopropanetricarboxylate
Synonyms: AS-4370
Molecular weight: 614
CAS: 112885-42-4
Purity: ≥98%
Formulation: A solid
