A STING agonist (IC50 = 0.3794 µM in a competition binding assay); activates STING in STING-expressing

CAY10748 – 5 mg

Brand:
Cayman
CAS:
2412902-55-5
Storage:
-20
UN-No:
Non-Hazardous - /

CAY10748 is an agonist of stimulator of interferon genes (STING; IC50 = 0.3794 µM in a competition binding assay).{50883} It activates STING in STING-expressing, but not STING knockout, THP-1 cells (EC50s = 0.287 and >100 µM, respectively, in a reporter assay). It induces phosphorylation of STING at the serine in position 366, as well as phosphorylation of TBK1 and IFN regulatory factor 3 (IRF3), indicating activation of the STING-TBK1-IRF3 signaling pathway. CAY10748 increases the secretion of IFN-β and the levels of chemokine (C-X-C motif) ligand 10 (CXCL10), and IL-6 in peripheral blood mononuclear cells (PBMCs) when used at a concentration of 10 µM. It also reduces tumor growth in a CT26 murine colon cancer model when administered at a dose of 0.15, but not 1.5, mg/kg.  

 

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SKU: 30022 - 5 mg Category:

Description

A STING agonist (IC50 = 0.3794 µM in a competition binding assay); activates STING in STING-expressing, but not STING knockout, THP-1 cells (EC50s = 0.287 and >100 µM, respectively, in a reporter assay); activates the STING-TBK1-IRF3 signaling pathway; increases the secretion of IFN-β and the levels of CXCL10 and IL-6 in PBMCs at 10 µM; reduces tumor growth in a CT26 murine colon cancer model at 0.15, but not 1.5, mg/kg

Formal name: benzyl (3-(5-carbamoyl-2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamido)-7-(3-methoxypropoxy)-1H-benzo[d]imidazol-1-yl)propyl)carbamate

Synonyms: 

Molecular weight: 591.7

CAS: 2412902-55-5

Purity: ≥98%

Formulation: A solid

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