An inhibitor of cyclin-dependent kinases (IC50s = 0.15

(S)-CR8 – 5 mg

Brand:
Cayman
CAS:
1084893-56-0
Storage:
-20
UN-No:
Non-Hazardous - /

(S)-CR8 is a second generation derivative of (R)-roscovitine (Item No. 10009569) and an inhibitor of cyclin-dependent kinase 1 (Cdk1/cyclin B), Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p25, and Cdk9/cyclin T (IC50s = 0.15, 0.08, 0.06, 0.12, and 0.11 µM, respectively).{21811} It also inhibits casein kinase CK1δ/ε (CKδ/ε) and DYRK1A (IC50s = 0.61 and 0.9 µM, respectively). (S)-CR8 reduces cell viability in human neuroblastoma cell lines, including SH-SY5Y, SK-N-AS, SK-N-BE, and IMR32 cells (IC50s = 0.43, 1.46, 0.13, and 0.14 µM, respectively).{21810} It also reduces protein levels of the survival factor Mcl-1 in SH-SY5Y cells.  

 

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SKU: 29985 - 5 mg Category:

Description

An inhibitor of cyclin-dependent kinases (IC50s = 0.15, 0.08, 0.06, 0.12, and 0.11 µM for Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p25, and Cdk9/cyclin T, respectively); inhibits CK1δ/ε and DYRK1A (IC50s = 0.61 and 0.9 µM, respectively); reduces cell viability in human neuroblastoma cell lines, including SH-SY5Y, SK-N-AS, SK-N-BE, and IMR32 cells (IC50s = 0.43, 1.46, 0.13, and 0.14 µM, respectively)

Formal name: (2S)-2-[[9-(1-methylethyl)-6-[[[4-(2-pyridinyl)phenyl]methyl]amino]-9H-purin-2-yl]amino]-1-butanol

Synonyms: 

Molecular weight: 431.5

CAS: 1084893-56-0

Purity: ≥98%

Formulation: A solid

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