A cyclic peptide antagonist of N-cadherin; inhibits neurite outgrowth in cerebellar neurons cultured on N-cadherin-expressing 3T3 cell monolayers (IC50 = 0.323 mM); inhibits cell scattering and motility induced by collagen I in Capan-1 cells and wild-type and N-cadherin-overexpressing BxPC-3 cells at 0.2 mg/ml; induces apoptosis in N-cadherin-overexpressing

ADH-1 – 10 mg

Brand:
Cayman
CAS:
229971-81-7
Storage:
-20
UN-No:
Non-Hazardous - /

ADH-1 is a cyclic peptide antagonist of N-cadherin. {46719} It inhibits neurite outgrowth in cerebellar neurons cultured on N-cadherin-expressing 3T3 cell monolayers (IC50 = 0.323 mM). ADH-1 (0.2 mg/ml) inhibits cell scattering and motility induced by collagen I in Capan-1 cells and wild-type and N-cadherin-overexpressing BxPC-3 cells.{46720} It induces apoptosis in N-cadherin-overexpressing, but not knockdown, BxPC-3 cells when used at a concentration of 1 mg/ml. ADH-1 (50 mg/kg) reduces tumor growth in an N-cadherin-overexpressing BxPC-3 mouse xenograft model.  

 

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SKU: 29981 - 10 mg Category:

Description

A cyclic peptide antagonist of N-cadherin; inhibits neurite outgrowth in cerebellar neurons cultured on N-cadherin-expressing 3T3 cell monolayers (IC50 = 0.323 mM); inhibits cell scattering and motility induced by collagen I in Capan-1 cells and wild-type and N-cadherin-overexpressing BxPC-3 cells at 0.2 mg/ml; induces apoptosis in N-cadherin-overexpressing, but not knockdown, BxPC-3 at 1 mg/ml; reduces tumor growth in an N-cadherin-overexpressing BxPC-3 mouse xenograft model at 50 mg/kg

Formal name: N-acetyl-L-cysteinyl-L-histidyl-L-alanyl-L-valyl-L-cysteinamide, cyclic (1→5)-disulfide

Synonyms:  N-Ac-CHAVC-NH2

Molecular weight: 570.7

CAS: 229971-81-7

Purity: ≥98%

Formulation: A solid

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