A class III antiarrhythmic agent; has antiadrenergic activity in isolated tissue preparations; an inhibitor of the Na+/K+-ATPase (IC50 = 4.5 mM); prevents ventricular fibrillation in anesthetized dogs in a model of sudden coronary death at 10 mg/kg; inhibits NCTs

Bretylium (tosylate) – 10 mg

Brand:
Cayman
CAS:
61-75-6
Storage:
-20
UN-No:
Non-Hazardous - /

Bretylium is a class III antiarrhythmic agent and an inhibitor of the Na+/K+-ATPase (IC50 = 4.5 mM).{46824} Bretylium also has antiadrenergic activity, inhibiting auricular nerve stimulation-induced vasoconstriction in isolated rabbit ears and hypogastric nerve stimulation-induced contraction of isolated rabbit uterus.{46827} It inhibits neuroeffector calcium transients (NCTs), as well as increases action potential delay and the absolute refractory period, but does not inhibit field stimulus-induced CTs in isolated mouse vas deferens sympathetic nerve terminals.{46828} Bretylium prevents ventricular fibrillation in anesthetized dogs in a model of sudden coronary death when administered at a dose of 10 mg/kg.{46829} Formulations containing bretylium were previously used in the prevention and treatment of ventricular fibrillation.  

 

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SKU: 29979 - 10 mg Category:

Description

A class III antiarrhythmic agent; has antiadrenergic activity in isolated tissue preparations; an inhibitor of the Na+/K+-ATPase (IC50 = 4.5 mM); prevents ventricular fibrillation in anesthetized dogs in a model of sudden coronary death at 10 mg/kg; inhibits NCTs, as well as increases action potential delay and the absolute refractory period in isolated mouse vas deferens sympathetic nerve terminals

Formal name: 2-bromo-N-ethyl-N,N-dimethyl-benzenemethanaminium, 4-methylbenzenesulfonate (1:1)

Synonyms: 

Molecular weight: 414.4

CAS: 61-75-6

Purity: ≥95%

Formulation: A crystalline solid

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