Description
An mTOR inhibitor (IC50 = 0.007 µM); selective for mTOR over PI3Kα and PI3Kγ (IC50s = 0.81 and 3.11 µM, respectively), as well as a panel of 24 additional kinases (IC50s = >50 µM for all); decreases phosphorylation of the mTORC1 and mTORC2 substrates Akt and S6K1, respectively, in a cell-free assay at 0.2, 1, and 5 µM; decreases proliferation of nine cancer cell lines (IC50s = 0.18-1.25 µM); inhibits survival of HL-60 and U937 leukemia cells; reduces tumor growth in a U937 mouse xenograft model at 5 and 25 mg/kg
Formal name: N-[4-[4-(4-morpholinyl)-1-[1-(3-pyridinylmethyl)-4-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-carbamic acid, methyl ester
Synonyms: WAY-687
Molecular weight: 528.6
CAS: 1062161-90-3
Purity: ≥98%
Formulation: A crystalline solid
