A mycotoxin; active against C. albicans and C. neoformans

Emestrin – 1 mg

Brand:
Cayman
CAS:
97816-62-1
Storage:
-20
UN-No:
Non-Hazardous - /

Emestrin is a mycotoxin originally isolated from E. striata that has antimicrobial, immunomodulatory, and cytotoxic activities.{48878,48879,48880,48881,48882} It is active against the fungi C. albicans and C. neoformans, as well as the bacteria E. coli, S. aureus, and methicillin-resistant S. aureus (MRSA; IC50s = 3.94, 0.6, 2.21, 4.55, and 2.21 µg/ml, respectively).{48879} Emestrin is a chemokine (C-C motif) receptor 2 (CCR2) antagonist (IC50 = 5.4 µM in a radioligand binding assay using isolated human monocytes).{48880} Emestrin (0.1 µg/ml) induces apoptosis in HL-60 cells.{48881} It induces heart, thymus, and liver tissue necrosis in mice when administered at doses ranging from 18 to 30 mg/kg.{48882}  

 

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SKU: 29970 - 1 mg Category:

Description

A mycotoxin; active against C. albicans and C. neoformans, as well as E. coli, S. aureus, and MRSA (IC50s = 3.94, 0.6, 2.21, 4.55, and 2.21 µg/ml, respectively); a CCR2 antagonist (IC50 = 5.4 µM in a radioligand binding assay using isolated human monocytes); induces apoptosis in HL-60 cells at 0.1 µg/ml; induces heart, thymus, and liver tissue necrosis in mice at 18-30 mg/kg

Formal name: (1R,2R,6aS,20S,21R,22bS)-6a,22b-dihydro-2,16,20-trihydroxy-12-methoxy-25-methyl-2H,8H,20H,22H-1,21-epidithio-21,1-(iminomethano)-9,13:15,19-dimetheno-4,7,14-trioxa-22a-azacyclononadec[cd]azulene-8,22,26-trione

Synonyms: 

Molecular weight: 598.6

CAS: 97816-62-1

Purity: ≥95%

Formulation: A solid

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