A neurotensin-like octapeptide; inhibits neurotensin binding to rat brain synaptic membranes (Ki = 1.5 nM); induces contraction of isolated guinea pig ileum in the presence of neostigmine (EC50 = 9 nM); increases the firing rate of dopaminergic neurons in rat substantia nigra slices by 58.5% at 0.1 μM; intravenous infusion increases adrenal

Xenopsin – 1 mg

Brand:
Cayman
CAS:
51827-01-1
Storage:
-20
UN-No:
Non-Hazardous - /

Xenopsin is a neurotensin-like octapeptide that has been found in X. laevis skin.{46783} It inhibits neurotensin (Item No. 24717) binding to rat brain synaptic membranes (Ki = 1.5 nM) and induces contraction of isolated guinea pig ileum in the presence of neostigmine (Item No. 23501; EC50 = 9 nM).{38912} Xenopsin (0.1 μM) increases the firing rate of dopaminergic neurons in rat substantia nigra slices by 58.5%.{46784} Intravenous infusion of xenopsin (2 μg/kg per hour) increases adrenal, pancreatic, and ileal blood flow and plasma levels of pancreatic polypeptide, glucagon, substance P, and cortisol, as well as reduces tetragastrin-induced gastric acid secretion in dogs.{46783}  

 

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Description

A neurotensin-like octapeptide; inhibits neurotensin binding to rat brain synaptic membranes (Ki = 1.5 nM); induces contraction of isolated guinea pig ileum in the presence of neostigmine (EC50 = 9 nM); increases the firing rate of dopaminergic neurons in rat substantia nigra slices by 58.5% at 0.1 μM; intravenous infusion increases adrenal, pancreatic, and ileal blood flow and plasma levels of pancreatic polypeptide, glucagon, substance P, and cortisol, as well as reduces tetragastrin-induced gastric acid secretion in dogs at 2 μg/kg per hour

Formal name: 5-oxo-L-prolylglycyl-L-lysyl-L-arginyl-L-prolyl-L-tryptophyl-L-isoleucyl-L-leucine

Synonyms:  pGlu-Gly-Lys-Arg-Pro-Trp-Ile-Leu

Molecular weight: 980.2

CAS: 51827-01-1

Purity: ≥98%

Formulation: A crystalline solid

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