A TRPML1 agonist; induces cytosolic calcium increases in HEK293T cells expressing surface-expressed mutant TRPML1 channels at 10 µM; activates TRPML1-mediated current (IML1) in isolated vacuoles that were enlarged by vacuolin-1 prior to isolation from HEK293 cells expressing TRPML1; activates whole-endolysosome IML1 in primary murine macrophages

ML-SA1 – 10 mg

Brand:
Cayman
CAS:
332382-54-4
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

ML-SA1 is an agonist of transient receptor potential mucolipin 1 (TRPML1).{46901} It induces cytosolic calcium increases in HEK293T cells expressing surface-expressed mutant TRPML1 channels when used at a concentration of 10 µM. ML-SA1 activates TRPML1-mediated current (IML1) in isolated vacuoles that were enlarged by vacuolin-1 (Item No. 20425) prior to isolation from HEK293 cells expressing TRPML1. It also activates whole-endolysosome IML1 in primary murine macrophages.  

 

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SKU: 29958 - 10 mg Category:

Description

A TRPML1 agonist; induces cytosolic calcium increases in HEK293T cells expressing surface-expressed mutant TRPML1 channels at 10 µM; activates TRPML1-mediated current (IML1) in isolated vacuoles that were enlarged by vacuolin-1 prior to isolation from HEK293 cells expressing TRPML1; activates whole-endolysosome IML1 in primary murine macrophages

Formal name: 2-[2-(3,4-dihydro-2,2,4-trimethyl-1(2H)-quinolinyl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione

Synonyms:  Mucolipin synthetic agonist 1

Molecular weight: 362.4

CAS: 332382-54-4

Purity: ≥98%

Formulation: A crystalline solid

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