A fungal metabolite; active against the P. falciparum strain K1 (IC50 = 7.9 µg/ml) and L. amazonensis promastigotes (IC50 = 23.7 µM)

Butyrolactone V – 1 mg

Brand:
Cayman
CAS:
1151509-01-1
Storage:
-20
UN-No:
Non-Hazardous - /

Butyrolactone V is a fungal metabolite that has been found in A. terreus and has antiprotozoal, antioxidant, and anticancer activities.{52309,52310,52311} It is active against the P. falciparum strain K1 (IC50 = 7.9 µg/ml) and L. amazonensis promastigotes (IC50 = 23.7 µM).{52310,52309} Butyrolactone V (227 and 454.1 µM) is also active against adult S. mansoni worms.{52309} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) and ABTS (Item No. 27317) radicals with IC50 values of 20.7 and 3.7 µM, respectively, in cell-free assays.{52311} Butyrolactone V also inhibits proliferation of MDA-MB-231 and MCF-7 breast cancer cells (IC50s = 22.2 and 31.9 µM, respectively).{52309}  

 

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Description

A fungal metabolite; active against the P. falciparum strain K1 (IC50 = 7.9 µg/ml) and L. amazonensis promastigotes (IC50 = 23.7 µM), as well as adult S. mansoni worms at 227 and 454.1 µM; scavenges DPPH and ABTS radicals (IC50s = 20.7 and 3.7 µM, respectively, in cell-free assays); inhibits proliferation of MDA-MB-231 and MCF-7 breast cancer cells (IC50s = 22.2 and 31.9 µM, respectively)

Formal name: (2R)-2-[[(3S)-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl]methyl]-2,5-dihydro-4-hydroxy-3-(4-hydroxyphenyl)-5-oxo-2-Furancarboxylic acid, methyl ester

Synonyms: 

Molecular weight: 440.4

CAS: 1151509-01-1

Purity: ≥95%

Formulation: A solid

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