A bacterial metabolite with diverse biological activities; active against KB carcinoma cells

Sparsomycin – 5 mg

Brand:
Cayman
CAS:
1404-64-4
Storage:
-20
UN-No:
Non-Hazardous - /

Sparsomycin is a bacterial metabolite and a nucleoside analog of uracil that has been found in S. sparsogenes and has diverse biological activities.{53394,22680,53395} It is active against KB carcinoma cells, Gram-positive and Gram-negative bacteria, and fungi.{53396} Sparsomycin is an inhibitor of peptidyl transferase that interferes with tRNA binding to the A-site of the peptidyl transfer center and increases the binding of peptidyl-tRNA to the P-site.{22680} It inhibits protein synthesis in bacteria, archaea, and eukaryotes.{22680,53395} Sparsomycin reduces tumor growth in a P388 mouse leukemia model and in a Walker 256 carcinosarcoma rat model.{53397}  

 

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Description

A bacterial metabolite with diverse biological activities; active against KB carcinoma cells, Gram-positive and Gram-negative bacteria, and fungi; an inhibitor of peptidyl transferase; inhibits protein synthesis in bacteria, archaea, and eukaryotes; reduces tumor growth in a P388 mouse leukemia model and in a Walker 256 carcinosarcoma rat model

Formal name: (2E)-N-[(1S)-1-(hydroxymethyl)-2-[(R)-[(methylthio)methyl]sulfinyl]ethyl]-3-(1,2,3,4-tetrahydro-6-methyl-2,4-dioxo-5-pyrimidinyl)-2-propenamide

Synonyms:  (+)-Sparsomycin|NSC 059729|NSC 59729|U-19183

Molecular weight: 361.4

CAS: 1404-64-4

Purity: ≥95%

Formulation: A solid

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