Description
A galanin receptor agonist (KD = 2.9 µM in Bowes cells expressing GAL1 receptors); inhibits forskolin-induced adenylate cyclase activity in rat hippocampal membranes (EC50 = 10 µM); reduces the maximal seizure score and increases the latency to first seizure in a mouse model of PTZ-induced seizures at 2 mg/kg; reduces cocaine-induced motor activity and frontal cortex, but not nucleus accumbens, dopamine overflow, as well as blocks cocaine-primed reinstatement of cocaine-seeking behavior in rats; reduces food intake in rats and mice from 1.5-5 mg/kg
Formal name: 3-cyclohexyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-lysinamide, trifluoroacetate salt
Synonyms: Fmoc-β-Cha-Lys-AMC
Molecular weight: 792.9
CAS: 1217448-19-5
Purity: ≥98%
Formulation: A crystalline solid
