An inhibitor of NMMT (IC50s = 1.8

JBSNF-000088 – 1 g

Brand:
Cayman
CAS:
7150-23-4
Storage:
-20
UN-No:
Non-Hazardous - /

JBSNF-000088 is an inhibitor of nicotinamide N-methyltransferase (NNMT; IC50s = 1.8, 2.8, and 5 µM for human, monkey, and mouse NNMT, respectively).{50847} It inhibits NNMT and reduces 1-methyl-nicotinamide (MNA) levels in U2OS and 3T3L1 cells (IC50s = 1.6 and 6.3 µM, respectively). JBSNF-000088 (50 mg/kg) reduces visceral white adipose tissue (WAT) MNA levels, body weight, fed blood glucose levels, and plasma and liver triglyceride levels, and improves oral glucose tolerance in a mouse model of diet-induced obesity (DIO). It also improves glucose tolerance, without affecting body weight, in the ob/ob and db/db mouse models of insulin resistance and diabetes, respectively.  

 

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SKU: 29920 - 1 g Category:

Description

An inhibitor of NMMT (IC50s = 1.8, 2.8, and 5 µM for human, monkey, and mouse NNMT, respectively); inhibits NNMT and reduces MNA levels in U2OS and 3T3L1 cells (IC50s = 1.6 and 6.3 µM, respectively); reduces visceral WAT, MNA levels, body weight, fed blood glucose levels, and plasma and liver triglyceride levels, and improves oral glucose tolerance in a mouse model of DIO; also improves glucose tolerance, without affecting body weight, in the ob/ob and db/db mouse models of insulin resistance and diabetes, respectively

Formal name: 6-methoxy-3-pyridinecarboxamide

Synonyms:  6-Methoxynicotinamide|NSC 70628

Molecular weight: 152.2

CAS: 7150-23-4

Purity: ≥98%

Formulation: A solid

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