Description
A diarylnonanoid with diverse biological activities; an inhibitor of sphingomyelin synthase 1 and -2 (IC50s = 3.5 and 2.5 µM, respectively); active against S. aureus, B. subtilis, and S. durans (MIC = 1 µg/ml for all) and three strains of C. albicans (MICs = 4-16 µg/ml); cytotoxic to A549, A375, Jurkat, A431, U937, and MCF-7 cells (IC50s = 8.1, 26.7, 27.4, 9.5, 27.5, and 9.3 µM, respectively) but not non-cancerous cells; increases the levels of ROS and induces apoptosis in A549 cells; reduces TBARS formation by 28.2% in rat liver mitochondria at 2 µg/ml; reduces stomach ulceration in a mouse model of indomethacin-induced gastric ulcer at 10, 15, and 20 mg/kg
Formal name: 1-(2,6-dihydroxyphenyl)-9-(4-hydroxyphenyl)-1-nonanone
Synonyms: NSC 287967|NSC 630196
Molecular weight: 342.4
CAS: 63335-24-0
Purity: ≥98%
Formulation: A crystalline solid
