A diarylnonanoid with diverse biological activities; an inhibitor of sphingomyelin synthase 1 and -2 (IC50s = 3.5 and 2.5 µM

Malabaricone B – 10 mg

Brand:
Cayman
CAS:
63335-24-0
Storage:
-20
UN-No:
Non-Hazardous - /

Malabaricone B is a diarylnonanoid that has been found in Myristica and has diverse biological activities, including enzyme inhibitory, antimicrobial, anticancer, and antioxidant properties.{50203,45637,50868,45636,50861} It is an inhibitor of sphingomyelin synthase 1 and -2 (IC50s = 3.5 and 2.5 µM, respectively, in fibroblast cell lysates).{50203} It is active against the bacteria S. aureus, B. subtilis, and S. durans (MIC = 1 µg/ml for all) and three strains of the fungus C. albicans (MICs = 4-16 µg/ml).{45637} It is cytotoxic to A549, A375, Jurkat, A431, U937, and MCF-7 cells (IC50s = 8.1, 26.7, 27.4, 9.5, 27.5, and 9.3 µM, respectively) but not non-cancerous INT407, HEK293, or WI-38 cells.{50868} It increases the levels of intracellular reactive oxygen species (ROS) and induces apoptosis in A549 cells. It reduces the formation of thiobarbituric acid reactive substrates (TBARS) by 28.2% in rat liver mitochondria when used at a concentration of 2 µg/ml but scavenges only 5% of 2,2-diphenyl-picrylhydrazyl (DPPH; Item No. 14805) radicals at 7 µg/ml.{45636} Malabaricone B (10, 15, and 20 mg/kg) reduces stomach ulceration in a mouse model of indomethacin-induced gastric ulcer.{50861}  

 

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Description

A diarylnonanoid with diverse biological activities; an inhibitor of sphingomyelin synthase 1 and -2 (IC50s = 3.5 and 2.5 µM, respectively); active against S. aureus, B. subtilis, and S. durans (MIC = 1 µg/ml for all) and three strains of C. albicans (MICs = 4-16 µg/ml); cytotoxic to A549, A375, Jurkat, A431, U937, and MCF-7 cells (IC50s = 8.1, 26.7, 27.4, 9.5, 27.5, and 9.3 µM, respectively) but not non-cancerous cells; increases the levels of ROS and induces apoptosis in A549 cells; reduces TBARS formation by 28.2% in rat liver mitochondria at 2 µg/ml; reduces stomach ulceration in a mouse model of indomethacin-induced gastric ulcer at 10, 15, and 20 mg/kg

Formal name: 1-(2,6-dihydroxyphenyl)-9-(4-hydroxyphenyl)-1-nonanone

Synonyms:  NSC 287967|NSC 630196

Molecular weight: 342.4

CAS: 63335-24-0

Purity: ≥98%

Formulation: A crystalline solid

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