A MIF inhibitor; decreases skin thickness and MPO activity and induces keratinocyte apoptosis

CPSI-1306 – 50 mg

Brand:
Cayman
CAS:
1309793-47-2
Storage:
-20
UN-No:
Non-Hazardous - /

CPSI-1306 is an inhibitor of macrophage inhibitory factor (MIF).{53398,53399} In vivo, CPSI-1306 (20 mg/kg per day) decreases skin thickness and myeloperoxidase (MPO) activity and induces keratinocyte apoptosis, as well as reduces papilloma formation and progression to micro-invasive squamous cell carcinoma (SCC) in a mouse model of UVB-induced SCC.{53398} It lowers blood glucose levels and serum levels of IL-6 and TNF-α in a mouse model of non-insulin-dependent diabetes mellitus (NIDDM) induced by streptozotocin (Item No. 13104).{53399}  

 

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SKU: 29905 - 50 mg Category:

Description

A MIF inhibitor; decreases skin thickness and MPO activity and induces keratinocyte apoptosis, as well as reduces papilloma formation and progression to micro-invasive SCC in a mouse model of UVB-induced SCC at 20 mg/kg per day; lowers blood glucose levels and serum levels of IL-6 and TNF-α in a mouse model of streptozotocin-induced NIDDM

Formal name: 2-[3-(2,4-difluorophenyl)-4,5-dihydro-5-isoxazolyl]-1-(4-morpholinyl)-ethanone

Synonyms: 

Molecular weight: 310.3

CAS: 1309793-47-2

Purity: ≥95%

Formulation: A crystalline solid

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