An inhibitor of Rab27a-JFC1 protein-protein interactions (IC50 = 2.6 µM); inhibits GM-CSF and fMLP-induced MPO secretion from isolated human neutrophils (IC50 = 0.33 µM); reduces LPS-induced increases in plasma MPO levels

Nexinhib20 – 25 mg

Brand:
Cayman
CAS:
331949-35-0
Storage:
-20
UN-No:
Non-Hazardous - /

Nexinhib20 is an inhibitor of the protein-protein interaction between the small GTPase Rab27a and its effector JFC1 (IC50 = 2.6 µM).{46766} It inhibits myeloperoxidase (MPO) secretion induced by granulocyte macrophage colony-stimulating factor (GM-CSF) and fMLP in isolated human neutrophils (IC50 = 0.33 µM). Nexinhib20 (30 mg/kg) reduces LPS-induced increases in plasma MPO levels, as well as LPS-induced hepatic and renal neutrophil infiltration in a mouse model of endotoxin-induced systemic inflammation.  

 

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SKU: 29899 - 25 mg Category:

Description

An inhibitor of Rab27a-JFC1 protein-protein interactions (IC50 = 2.6 µM); inhibits GM-CSF and fMLP-induced MPO secretion from isolated human neutrophils (IC50 = 0.33 µM); reduces LPS-induced increases in plasma MPO levels, as well as LPS-induced hepatic and renal neutrophil infiltration in a mouse model of endotoxin-induced systemic inflammation

Formal name: 4,4-dimethyl-1-(3-nitrophenyl)-2-(1H-1,2,4-triazol-1-yl)-1-penten-3-one

Synonyms: 

Molecular weight: 300.3

CAS: 331949-35-0

Purity: ≥98%

Formulation: A crystalline solid

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