An active metabolite of ifosfamide; formed through hydroxylation of ifosfamide by various hepatic CYP isoforms; cytotoxic to L1210 and CCRF-CEM cancer cells at 100 µM; reduces tumor growth in Lewis lung carcinoma and L1210 leukemia mouse models

Palifosfamide – 100 mg

Brand:
Cayman
CAS:
31645-39-3
Storage:
-20
UN-No:
Non-Hazardous - /

Palifosfamide is an active metabolite of the DNA alkylating agent ifosfamide (Item No. 17562).{52428} Palifosfamide is formed through hydroxylation of ifosfamide by various hepatic cytochrome P450 (CYP) isoforms.{52429} It is cytotoxic to L1210 and CCRF-CEM cancer cells when used at a concentration of 100 µM.{52430} Palifosfamide (100 mg/kg per day) reduces tumor growth in murine Lewis lung carcinoma and L1210 leukemia models, as well as a rat Yoshida ascitic sarcoma model.{52428}  

 

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SKU: 29887 - 100 mg Category:

Description

An active metabolite of ifosfamide; formed through hydroxylation of ifosfamide by various hepatic CYP isoforms; cytotoxic to L1210 and CCRF-CEM cancer cells at 100 µM; reduces tumor growth in Lewis lung carcinoma and L1210 leukemia mouse models, as well as a rat Yoshida ascitic sarcoma model at 100 mg/kg per da

Formal name: N,N′-bis(2-chloroethyl)-phosphorodiamidic acid

Synonyms:  Isophosphoramide Mustard|NSC 297900

Molecular weight: 221

CAS: 31645-39-3

Purity: ≥95%

Formulation: A crystalline solid

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