A flavonoid with diverse biological activities; scavenges DPPH and peroxynitrite radicals in cell-free assays (IC50s = 2.2 and 5.78 µM

7,3′,4′-Trihydroxyflavone – 25 mg

Brand:
Cayman
CAS:
2150-11-0
Storage:
-20
UN-No:
Non-Hazardous - /

7,3’,4’-Trihydroxyflavone is a flavonoid that has been found in A. julibrissin bark and has diverse biological activities.{52324,52325,52326,52327} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) and peroxynitrite radicals in cell-free assays (IC50s = 2.2 and 5.78 µM, respectively), as well as reduces total reactive oxygen species in rat kidney homogenates (IC50 = 3.9 µM).{52324} 7,3’,4’-Trihydroxyflavone inhibits COX-1 (IC50 = 36.7 µM).{52325} It is active against M. tuberculosis (MIC = 50 µg/ml).{52326} It decreases mRNA expression of the osteoclastic marker genes encoding the calcitonin receptor, cathepsin K1 V-ATPase V0 subunit d2 (Atp6v0d2), and dendritic cell specific transmembrane protein (Dcstamp) in and inhibits RANKL-induced osteoclastic differentiation of mouse bone marrow-derived macrophages (BMDMs).{52327}  

 

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SKU: 29880 - 25 mg Category:

Description

A flavonoid with diverse biological activities; scavenges DPPH and peroxynitrite radicals in cell-free assays (IC50s = 2.2 and 5.78 µM, respectively), as well as reduces total reactive oxygen species in rat kidney homogenates (IC50 = 3.9 µM); inhibits COX-1 (IC50 = 36.7 µM); active against M. tuberculosis (MIC = 50 µg/ml); decreases mRNA expression of the osteoclastic marker genes encoding the calcitonin receptor, Atp6v0d2, and Dcstamp in and inhibits RANKL-induced osteoclastic differentiation of mouse BMDMs

Formal name: 2-(3,4-dihydroxyphenyl)-7-hydroxy-4H-1-benzopyran-4-one

Synonyms:  3’,4’,7-Trihydroxyflavone|5-Deoxyluteolin

Molecular weight: 270.2

CAS: 2150-11-0

Purity: ≥98%

Formulation: A crystalline solid

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