An endogenous metabolite of tryptophan; activates AhR in a reporter assay at 50 and 250 µM; topical administration reduces the severity of UVB-induced damage in mouse skin at 100 µmol; reduces diarrhea

Indole-3-pyruvic Acid – 1 g

Brand:
Cayman
CAS:
392-12-1
Storage:
-20
UN-No:
Non-Hazardous - /

Indole-3-pyruvic acid is an endogenous metabolite of tryptophan and intermediate in the biosynthesis of the major auxin hormone, indole-3-acetic acid (IAA; Item No. 16954), in plants.{52871,52872,52873} Indole-3-pyruvic acid (50 and 250 µM) activates the aryl hydrocarbon receptor (AhR) in a reporter assay.{52871} It reduces UVB-induced cytotoxicity and the levels of COX-2 in HaCaT keratinocytes.{52874} Topical administration of indole-3-pyruvic acid (100 µmol) reduces the severity of UVB-induced damage in mouse skin. Dietary administration of indole-3-pyruvic acid (0.1%) reduces diarrhea, colonic inflammation, and the colonic expression of Il1b, Ifng, Tnfa, and Il12b in a mouse model of T cell-mediated colitis.{52871} It increases the time spent in the open arms of the elevated plus maze in mice when administered at a dose of 100 mg/kg.{52872} It also reverses the anxiogenic effect of caffeine (Item No. 14118) and 3-hydroxy kynurenine, but not pentylenetetrazole (Item No. 18682) or phenylethylamine, in the elevated plus maze in mice.  

 

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Description

An endogenous metabolite of tryptophan; activates AhR in a reporter assay at 50 and 250 µM; topical administration reduces the severity of UVB-induced damage in mouse skin at 100 µmol; reduces diarrhea, colon inflammation, and the colonic expression of Il1b, Ifng, Tnfa, and Il12b in a mouse model of T cell-mediated colitis at 0.1% in the diet; increases the time spent in the open arms of the elevated plus maze in mice at 100 mg/kg

Formal name: α-oxo-1H-Indole-3-propanoic acid

Synonyms:  Indole-3-pyruvate|IPA|IPyr|NSC 88874

Molecular weight: 203.2

CAS: 392-12-1

Purity: ≥98%

Formulation: A crystalline solid

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