A DNA topoisomerase I and II inhibitor (IC50s = 2 and 6.5 µM

TAS 103 (hydrochloride) – 100 mg

Brand:
Cayman
CAS:
174634-09-4
Storage:
-20
UN-No:
Non-Hazardous - /

TAS 103 is an inhibitor of DNA topoisomerase I and II (IC50s = 2 and 6.5 µM, respectively).{57221} It stabilizes topoisomerase I-DNA and topoisomerase II-DNA cleavable complexes in KB cells when used at a concentration of 3 µM. It is cytotoxic to P388 and KB cells (IC50s = 1.1 and 9.6 nM, respectively). TAS 103 (15, 26, and 45 mg/kg per day) reduces pulmonary metastasis in murine B16-BL6 melanoma and UV-2237M fibrosarcoma models of lung metastasis. It also reduces tumor growth in a variety of human cancer mouse xenograft models.  

 

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SKU: 29869 - 100 mg Category:

Description

A DNA topoisomerase I and II inhibitor (IC50s = 2 and 6.5 µM, respectively); stabilizes topoisomerase I-DNA and topoisomerase II-DNA cleavable complexes in KB cells at 3 µM; cytotoxic to P388 and KB cells (IC50s = 1.1 and 9.6 nM, respectively); reduces pulmonary metastasis in murine B16-BL6 melanoma and UV-2237M fibrosarcoma models of lung metastasis at 15, 26, and 45 mg/kg per day; reduces tumor growth in a variety of human cancer mouse xenograft models

Formal name: 6-[[2-(dimethylamino)ethyl]amino]-3-hydroxy-7H-indeno[2,1-c]quinolin-7-one, dihydrochloride

Synonyms: 

Molecular weight: 406.3

CAS: 174634-09-4

Purity: ≥98%

Formulation: A crystalline solid

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