An inhibitor of NF-κB/AP-1 (IC50 = 2.3 µM in a reporter assay); inhibits the production of TNF-α and IL-6 production in human Mono-Mac-6 cells (IC50s = 1.3 and 3.8 µM

IQ-1S (free acid) – 10 mg

Brand:
Cayman
CAS:
23146-22-7
Storage:
-20
UN-No:
Non-Hazardous - /

IQ-1S (free acid) is an inhibitor of NF-κB/AP-1 (IC50 = 2.3 µM in a reporter assay).{52381} It inhibits TNF-α and IL-6 production in human Mono-Mac-6 cells (IC50s = 1.3 and 3.8 µM, respectively) and isolated human peripheral blood mononuclear cells (PBMCs; IC50s = 2.6 and 5.6 µM, respectively), as well as nitric oxide (NO) production in murine J774-A.1 macrophages (IC50 = 3.1 µM). IQ-1S (free acid) binds to JNKs (Kd = 0.24, 0.36, and 0.1µM for JNK1-3), as well as casein kinase 1δ (CK1δ), PI3Kγ, and MAPK-interacting serine/threonine kinase 2 (MKNK2; Kds = 0.38, 0.47, and 0.92 µM, respectively).  

 

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SKU: 29851 - 10 mg Category:

Description

An inhibitor of NF-κB/AP-1 (IC50 = 2.3 µM in a reporter assay); inhibits the production of TNF-α and IL-6 production in human Mono-Mac-6 cells (IC50s = 1.3 and 3.8 µM, respectively) and isolated human PBMCs (IC50s = 2.6 and 5.6 µM, respectively), as well as NO production in murine J774-A.1 macrophages (IC50 = 3.1 µM); binds to JNKs (Kd = 0.24, 0.36, and 0.1 for JNK1-3), as well as CK1δ, PI3Kγ, and MKNK2 (Kds = 0.38, 0.47, and 0.92 µM, respectively)

Formal name: 11H-indeno[1,2-b]quinoxalin-11-one, oxime

Synonyms:  IQ-1

Molecular weight: 247.3

CAS: 23146-22-7

Purity: ≥98%

Formulation: A solid

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