A prodrug form of cilazaprilat; inhibits plasma ACE activity and inhibits the angiotensin I-induced pressor response in anesthetized rats and cats at 0.1 mg/kg; decreases systolic blood pressure in spontaneously hypertensive rats at 30 mg/kg; decreases blood pressure in volume-depleted renal hypertensive dogs at 10 mg/kg

Cilazapril – 1 mg

Brand:
Cayman
CAS:
88768-40-5
Storage:
-20
UN-No:
Non-Hazardous - /

Cilazapril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor cilazaprilat.{46686} In vivo, cilazapril (0.1 mg/kg) inhibits plasma ACE activity and inhibits the angiotensin I-induced pressor response in anesthetized rats and cats. It decreases systolic blood pressure in spontaneously hypertensive rats when administered at a dose of 30 mg/kg. Cilazapril (10 mg/kg, p.o.) decreases blood pressure in volume-depleted renal hypertensive dogs. Formulations containing cilazapril have been used in the treatment of hypertension.  

 

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SKU: 29777 - 1 mg Category:

Description

A prodrug form of cilazaprilat; inhibits plasma ACE activity and inhibits the angiotensin I-induced pressor response in anesthetized rats and cats at 0.1 mg/kg; decreases systolic blood pressure in spontaneously hypertensive rats at 30 mg/kg; decreases blood pressure in volume-depleted renal hypertensive dogs at 10 mg/kg, p.o.

Formal name: (1S,9S)-9-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid

Synonyms:  Ro 31-2848

Molecular weight: 417.5

CAS: 88768-40-5

Purity: ≥98%

Formulation: A solid

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