A sesquiterpene lactone with diverse biological activities; inhibits LPS-induced increases in nitric oxide

Alantolactone – 25 mg

Brand:
Cayman
CAS:
546-43-0
Storage:
-20
UN-No:
Non-Hazardous - /

Alantolactone is a sesquiterpene lactone that has been found in Inula species and has diverse biological activities.{52342,52343,52344} It inhibits LPS-induced increases in nitric oxide, IL-6, and TNF-α production in RAW 246.7 cells by 76.09, 81.54, and 71.23%, respectively, when used at a concentration of 10 μM.{52342} Alantolactone (40 μM) decreases cell viability, glutathione (GSH) levels, and the mitochondrial membrane potential, induces apoptosis, and increases generation of reactive oxygen species (ROS) in HepG2 cells.{52343} It inhibits phosphorylation and nuclear translocation of STAT3 in MDA-MB-231 cells in a concentration-dependent manner.{52344} Alantolactone (2.5 mg/kg) reduces tumor growth in an MDA-MB-231 mouse xenograft model.  

 

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SKU: 29762 - 25 mg Category:

Description

A sesquiterpene lactone with diverse biological activities; inhibits LPS-induced increases in nitric oxide, IL-6, and TNF-α production in RAW 246.7 cells by 76.09, 81.54, and 71.23%, respectively, at 10 μM; decreases cell viability, GSH levels, and the mitochondrial membrane potential, induces apoptosis, and increases ROS generation in HepG2 cells at 40 μM; inhibits phosphorylation and nuclear translocation of STAT3 in MDA-MB-231 cells; reduces tumor growth in an MDA-MB-231 mouse xenograft model at 2.5 mg/kg

Formal name: (3aR,5S,8aR,9aR)-3a,5,6,7,8,8a,9,9a-octahydro-5,8a-dimethyl-3-methylene-naphtho[2,3-b]furan-2(3H)-one

Synonyms:  (+)-Alantolactone|NSC 333843|NSC 93131

Molecular weight: 232.3

CAS: 546-43-0

Purity: ≥98%

Formulation: A crystalline solid

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