A noncompetitive antagonist and inverse agonist of mGluR5 that binds to an allosteric site; inhibits quisqualate-induced intracellular calcium mobilization in HEK293 cells expressing the human receptor (IC50 = 58 nM); inhibits basal activity of mGluR5 in a cell-based assay (IC50 = 84 nM); reduces stress-induced hyperthermia in mice at 10 and 30 mg/kg; increases drinking time in the Vogel conflict test in rats at 30 mg/kg; induces analgesia in the formalin test in mice at 30 mg/kg

Fenobam (hydrate) – 10 mg

Brand:
Cayman
CAS:
63540-28-3
Storage:
-20
UN-No:
Non-Hazardous - /

Fenobam is a noncompetitive antagonist and inverse agonist of metabotropic glutamate receptor 5 (mGluR5) that binds to an allosteric site.{52400} It inhibits intracellular calcium mobilization induced by the glutamate analog quisqualate (Item No. 20211) in HEK293 cells expressing the human receptor (IC50 = 58 nM) and inhibits basal activity of mGluR5 in a cell-based assay (IC50 = 84 nM).{52400} Fenobam (10 and 30 mg/kg) reduces stress-induced hyperthermia in mice and increases drinking time in the Vogel conflict test in rats when administered at a dose of 30 mg/kg, indicating anxiolytic-like activity. It induces analgesia in the formalin test in mice when administered at a dose of 30 mg/kg.{52401}  

 

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SKU: 29759 - 10 mg Category:

Description

A noncompetitive antagonist and inverse agonist of mGluR5 that binds to an allosteric site; inhibits quisqualate-induced intracellular calcium mobilization in HEK293 cells expressing the human receptor (IC50 = 58 nM); inhibits basal activity of mGluR5 in a cell-based assay (IC50 = 84 nM); reduces stress-induced hyperthermia in mice at 10 and 30 mg/kg; increases drinking time in the Vogel conflict test in rats at 30 mg/kg; induces analgesia in the formalin test in mice at 30 mg/kg

Formal name: N-(3-chlorophenyl)-N′-(4,5-dihydro-1-methyl-4-oxo-1H-imidazol-2-yl)-urea, monohydrate

Synonyms: 

Molecular weight: 284.7

CAS: 63540-28-3

Purity: ≥98%

Formulation: A crystalline solid

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