Oxfendazole is a benzimidazole anthelmintic.{58095,58096} In vivo, oxfendazole is curative in pig models of H. rubidus or A. suum infection when administered at doses of 3 and 6 mg/kg, respectively.{58095} It is lethal to H. contortus and T. circumcincta when administered to infected cattle (LD50s = 4.28 and 3.61 mg/kg of host weight, respectively).{58096} Formulations containing oxfendazole have been used in the treatment and prevention of helminth infections in livestock.
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An anthelmintic; curative in pig models of H. rubidus or A. suum infection at 3 and 6 mg/kg, respectively; is lethal to H. contortus and T. circumcincta when administered to infected cattle (LD50s = 4.28 and 3.61 mg/kg of host weight, respectively)
Formal name: N-[6-(phenylsulfinyl)-1H-benzimidazol-2-yl]-carbamic acid, methyl ester
Synonyms: Fenbendazole sulfoxide|HOE 8105|Oxfenbendazole
Molecular weight: 315.3
CAS: 53716-50-0
Purity: ≥98%
Formulation: A crystalline solid
1,2-Dipalmitoyl-sn-glycero-3-PC (DPPC) is a zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers, bilayers, and liposomes for use in a variety of applications.{14480,24261,14478,14479} It has been used in the formation of proteoliposomes for implantation of γ-glutamyl transpeptidase into human erythrocyte membranes.{14478} Incorporation of glycosphingolipid antigens into DPPC-containing liposomes increases the immunogenicity of the antigens in mice.{14479}
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The PtdIn phosphates play an important role in the generation and transduction of intracellular signals.{8344,4096,14518} PtdIns-(3,4,5)-P3-biotin is an affinity probe which allows the PIP3 to be detected through an interaction with the biotin ligand. This design allows PtdIns-(3,4,5)-P3-biotin to serve as a general probe for any protein with a high affinity binding interaction with inositol-(3,4,5)-triphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.
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1,2-Dipalmitoyl-sn-glycero-3-PC (DPPC) is a zwitterionic glycerophospholipid commonly used in the formation of lipid monolayers, bilayers, and liposomes for use in a variety of applications.{14480,24261,14478,14479} It has been used in the formation of proteoliposomes for implantation of γ-glutamyl transpeptidase into human erythrocyte membranes.{14478} Incorporation of glycosphingolipid antigens into DPPC-containing liposomes increases the immunogenicity of the antigens in mice.{14479}
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The nuclear factor-κB (NF-κB) regulates the expression of numerous genes involved in immunity and inflammation, cellular stress responses, growth, and apoptosis. Resveratrol, a polyphenolic trans-stilbene, is a known inhibitor of the activation of NF-κB and exhibits activity against a wide variety of cancer cells. CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}
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