A potent cathepsin S inhibitor (IC50 = 7.7 nM for the human enzyme); selective for cathepsin S over cathepsin L

LY3000328 – 1 mg

Brand:
Cayman
CAS:
1373215-15-6
Storage:
-20
UN-No:
Non-Hazardous - /

LY3000328 is a potent cathepsin S inhibitor (IC50 = 7.7 nM for the human enzyme).{53427} It is selective for cathepsin S over cathepsin L, K, B, and V (IC50s = >10,000, >10,000, 4,390, and 21,500 nM, respectively). LY3000328 (1-30 mg/kg) reduces aortic diameter in a mouse model of calcium chloride-induced abdominal aortic aneurysm.  

 

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SKU: 29729 - 1 mg Category:

Description

A potent cathepsin S inhibitor (IC50 = 7.7 nM for the human enzyme); selective for cathepsin S over cathepsin L, K, B, and V (IC50s = >10,000, >10,000, 4,390, and 21,500 nM, respectively); reduces aortic diameter in a mouse model of calcium chloride-induced abdominal aortic aneurysm from 1-30 mg/kg

Formal name: N-[(3R,4S)-3,4-dihydro-3-[[(methylamino)carbonyl]oxy]-6-[4-(3-oxetanyl)-1-piperazinyl]-2H-1-benzopyran-4-yl]-4-fluoro-benzamide

Synonyms: 

Molecular weight: 484.5

CAS: 1373215-15-6

Purity: ≥98%

Formulation: A crystalline solid

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