Description
An inhibitor of FLT3 kinase (IC50 = 0.015 µM); selective for FLT3 over Met, Ron, EGFR, and the insulin receptor (IC50s = >10 µM for all) but does inhibit DRAK2 (IC50 = 0.62 µM), as well as VEGFR2 and Aurora A (IC50s = 1.53 and 1.27 µM, respectively); inhibits proliferation of A549, SNU-638, HT-1080, HL-60, and MCF-7 cancer cells (IC50s = 13, 2.1, 3.4, 89, and 9 µM, respectively); inhibits proliferation of (IC50 = 5.1 µM), and induces apoptosis in, RK3E-ras cells and reduces tumor growth in RK3E-ras flank and oral tumor models; active against the parasite T. gondii (ID50 = 0.52 µM) with a TD50 value of 61 µM
Formal name: 3-[1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-5-fluoro-1,3-dihydro-2H-indol-2-one
Synonyms: 5’-FIO|5′-Fluoroindirubinoxime
Molecular weight: 295.3
CAS: 861214-33-7
Purity: ≥95%
Formulation: A crystalline solid
