Description
An inhibitor of α-glucosidase and α-1,6-glucosidase (IC50s = 0.42 and 8.4 μM, respectively); increases hepatic glycogen levels in fasted mice and gastrocnemius muscle glycogen levels in both fasted and fed mice at 250 mg/kg per day; increases β-glucosidase activity by 1.65-fold in patient-derived fibroblasts homozygous for the N370S Gaucher disease mutation when added to the culture medium at 5 μM, but inhibits β-glucosidase activity at >60 μM; DNJ inhibits viral replication in BHK-21 cells JEV or DEN-2); has protective effects in a mouse model of lethal JEV challenge at 200 mg/kg per day
Formal name: (2R,3R,4R,5S)-2-(hydroxymethyl)-1-nonyl-3,4,5-piperidinetriol
Synonyms: NN-DNJ|Nonyl-DNJ
Molecular weight: 289.4
CAS: 81117-35-3
Purity: ≥98%
Formulation: A solid
