A purine nucleotide and an intermediate in the purine nucleotide cycle; converted into AMP and fumarate by adenylosuccinate lyase in the cytosol; inhibits calcium-induced activation of non-selective cation channels in isolated rat brown adipocytes in a patch-clamp assay at 10 µM; increases glucose-induced insulin exocytosis in 832/13 INS-1 pancreatic β-cells at 10 µM; induces contractions in isolated guinea pig uterus strips at 100 µM

Adenylosuccinic Acid – 25 mg

Brand:
Cayman
CAS:
19046-78-7
Storage:
-20
UN-No:
Non-Hazardous - /

Adenylosuccinic acid is a purine nucleotide and an intermediate in the purine nucleotide cycle.{52338} It is converted into AMP and fumarate by adenylosuccinate lyase in the cytosol. Adenylosuccinic acid (10 µM) inhibits calcium-induced activation of non-selective cation channels in isolated rat brown adipocytes in a patch-clamp assay.{52339} Adenylosuccinic acid (10 µM) increases glucose-induced insulin exocytosis in 832/13 INS-1 pancreatic β-cells.{52340} It induces contractions in isolated guinea pig uterus strips when used at a concentration of 100 µM.{52341}  

 

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Description

A purine nucleotide and an intermediate in the purine nucleotide cycle; converted into AMP and fumarate by adenylosuccinate lyase in the cytosol; inhibits calcium-induced activation of non-selective cation channels in isolated rat brown adipocytes in a patch-clamp assay at 10 µM; increases glucose-induced insulin exocytosis in 832/13 INS-1 pancreatic β-cells at 10 µM; induces contractions in isolated guinea pig uterus strips at 100 µM

Formal name: N-[9-(5-O-phosphono-β-D-ribofuranosyl)-9H-purin-6-yl]-L-aspartic acid

Synonyms:  Aspartyl Adenylate|Succinyl Adenosine 5′-monophosphate|Succinyl AMP|Succinyladenosine monophosphoric Acid

Molecular weight: 463.3

CAS: 19046-78-7

Purity: ≥95%

Formulation: A crystalline solid

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